The Nissan 350Z (Z33, 2003–2009) is powered by the naturally aspirated 3.5L VQ35DE and later VQ35HR V6 engines, producing up to 306 hp and 268 lb-ft of torque, paired with a 6-speed manual or 5-speed automatic transmission and rear-wheel drive. Its chassis uses independent suspension, four-wheel disc brakes, a limited-slip differential, and a short-wheelbase layout developed specifically around the Z's rear-wheel-drive platform.

The 350Z kept the formula relatively simple with a naturally aspirated V6, manual gearbox, rear-wheel drive, and straightforward mechanical layout, while later versions added higher engine output and revised chassis tuning. Its strong aftermarket support, recognizable design, and connection to Nissan's earlier Z cars have helped keep the Z33 relevant among enthusiasts years after production ended.